The 2020 meeting will be held November 11–13, 2020 in a virtual format. More details to follow.

Wednesday, November 11, 2020

Session #1: Tumor Heterogeneity and Metastasis (9-10:30am PST, 12-1:30pm EST)

Invited speaker: Arthur Lander, University of California, Irvine
“Collective cell behaviors at the onset of cancer”

Invited speaker: Michael Murrell, Yale University
“Tissue Pressure drives traction-independent cellular flows”

Selected Abstract: Almudena Espin-Perez, Stanford University
“System level control of lineage plasticity in pancreas cancer”

Selected Abstract: Shubham Tripathi, Rice University
“A Mechanistic Modeling Framework Reveals the Key Principles Underlying Tumor Metabolism”

Poster Session (10:30-12am PST, 1:30-3pm EST)

Session #2: Cancer Evolution and Mechanisms of Resistance (12-1:30pm PST, 3-4:30pm EST)

Invited speaker: James Heath, Institute of Systems Biology
“Single Cell transcriptomic, proteomic, and metabolomic methods for tumor tissue analysis”

Invited speaker: Christina Curtis, Stanford University
“Characterizing the eco-evolutionary dynamics of tumor progression and resistance”

Selected Abstract: Robert A Beckman, Georgetown University
“Extensive Subclonal Mutational Diversity in Human Colorectal Cancer and Its Significance”

Selected Abstract: Mark Smithson, University of Utah
“Inferring evolutionary history of metastases with class and novel population genetic analyses”

Improving Inclusion in the Cancer Systems Biology Community (1:30-2:30pm PST, 4:30-5:30pm EST)

Thursday, November 12, 2020

Session #3: Signaling Networks in Cancer (9-10:30am PST, 12-1:30pm EST)

Invited speaker: Trachette Jackson, University of Michigan
“Mathematical model of Targeted Molecular Therapeutics”

Invited speaker: Kevin Janes, University of Virginia
“Systems-level identification of a single-cell bottleneck in premalignant glioma”

Selected Abstract: Hatice Osmanbeyoglu, University of Pittsburgh
“SPaRTAN, a computational framework for linking surface proteins to transcriptional regulators and single-cell genomic states”

Selected Abstract: Sabrina L. Spencer, University of Colorado-Boulder
“Melanoma subpopulations that rapidly escape MAPK pathway inhibition rely on stress signalling and incur DNA damage”

Mentorship session (10:30-12am PST, 1:30-3pm EST)

Session #4: Immunology and Microenvironment (12-1:30pm PST, 3-4:30pm EST)

Invited speaker: Pamela Kreeger, University of Wisconsin-Madison
“Systems approaches to ovarian cancer metastasis”

Invited speaker: Melody Swartz, University of Chicago
“Systems approaches to modeling the tumor-lymph-immune interface”

Selected Abstract: Dimitrios Sidiropoulos, Johns Hopkins University
“Integrative characterization of the Her2+ Breast Tumor Microenvironment with Entinostat & Immune Checkpoint Blockade Combination Therapies”

Selected Abstract: Janani Baskaran, Tufts University
“Cell shape, and not 2D migration, predicts extracellular matrix-driven 3D cell invasion in breast cancer”

Improving Inclusion in the Cancer Systems Biology Community (1:30-2:30pm PST, 4:30-5:30pm EST)

Friday, November 13

Session #5: Systems Pharmacology (9-10:30am PST, 12-1:30pm EST)

Invited speaker: Birgit Schoeberl, Novartis Institute for BioMedical Research
“Application of Systems Pharmacology in Drug Development”

Invited speaker: Sourav Bandyopadhyay, University of California, San Francisco
“An integrative approach to identify reproducible synthetic lethal interactions in cancer”

Selected Abstract: Andrew D Raddatz, Georgia Institute of Technology
“Kinetic Modeling of Nrf-2 Regulated Redox Metabolism Predicts Head and Neck Cancer Response to Reactive Oxygen Species Generating Chemotherapies”

Selected Abstract: Farnaz Mohammadi, University of California, Los Angeles
“Drug Treatment Induces Cell Cycle Pseudo-Synchronization Due to Phase Transit Times.”

Poster Session (10:30-12am PST, 1:30-3pm EST)

Session #6: Translational Systems Biology (12-1:30pm PST, 3-4:30pm EST)

Invited speaker: Thomas Yankeelov, University of Texas at Austin
“Towards personalized treatment regimens via quantitative imaging and mathematical modeling”

Invited speaker: Stacey Finley, University of Southern California
“Understanding and optimizing cell-based immunotherapies using systems biology models”

Selected Abstract: Emily Marcisak, Johns Hopkins University
“Matrix factorization of single-cell RNA-sequencing identifies novel immune cell states that project across species, cancer type, and infectious disease”

Selected Abstract: Zuzana Tatarova, Oregon Health Sciences University
“Personalized Combination Treatments and Early Anti-Tumor Immunity in Breast Cancer”

Closing remarks and socialization event (1:30-2:30pm PST, 4:30-5:30pm EST)

Note: Invited talks will be limited to 25 minutes. Selected talks will be limited to 15 minutes.